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Article

Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress.

American journal of physiology. Cell physiology - 1 Aug 2003

Numazawa Satoshi, Ishikawa Makie, Yoshida Aya, Tanaka Sachiko, Yoshida Takemi

Abstract excerpt

Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of antioxidative proteins, including heme oxygenase-1 (HO-1). Nrf2 is sequestered in the cytoplasm by Keap1 under unstimulated conditions but translocates into the nucleus and transactivates the antioxidant responsive elem...

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Identifiers

PMID: 12700136
DOI: 10.1152/ajpcell.00043.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12700136-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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