Article
Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol.
The Journal of biological chemistry - 5 Mar 2004
Martin Daniel, Rojo Ana I, Salinas Marta, Diaz Raquel, Gallardo German, Alam Jawed, De Galarreta Carlos M Ruiz, Cuadrado Antonio
Abstract excerpt
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway elicits a survival signal against multiple apoptotic insults. In addition, phase II enzymes such as heme oxygenase-1 (HO-1) protect cells against diverse toxins and oxidative stress. In this work, we describe a link between these defense systems at the level of transcriptional regulation of the antioxidant enzyme HO-1. The herb-derived phenol carnosol induced...
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