Article
An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome.
American journal of human genetics - 1 May 2003
Jaeger E E M, Woodford-Richens K L, Lockett M, Rowan A J, Sawyer E J, Heinimann K, Rozen P, Murday V A, Whitelaw S C, Ginsberg A, Atkin W S, Lynch H T, Southey M C, Debinski H, Eng C, Bodmer W F, Talbot I C, Hodgson S V, Thomas H J W, Tomlinson I P M
Abstract excerpt
The putative locus for hereditary mixed polyposis syndrome (HMPS) in a large family of Ashkenazi descent (SM96) was previously reported to map to chromosome sub-bands 6q16-q21. However, new clinical data, together with molecular data from additional family members, have shown 6q linkage to be incorrect. A high-density genomewide screen for the HMPS gene was therefore performed on SM96, using stringent criteria...
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