Article

Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of <i>Mycobacterium tuberculosis</i>

2018-11-08

Abstract excerpt

<h4>ABSTRACT</h4> The transcription factor Rv0081 of M. tuberculosis controls the hypoxic gene expression and acts as a regulatory hub in the latent phase of tuberculosis infection. We report here the crystal structure of Rv0081 at 3.3 Å resolution revealing that it belongs to the well-known ArsR/SmtB family proteins. ArsR/SmtB family transcriptional repressors exert gene regulation by reversible metal binding....

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Literature Corpus work: be4865cd-ca7e-5fab-9aba-34ddaeaa72c7
DOI: 10.1101/465575

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