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Article

Flock House Virus Induces Apoptosis by Depletion of <i>Drosophila</i> Inhibitor-of-Apoptosis Protein DIAP1

8 Nov 2007

Abstract excerpt

The molecular mechanisms by which RNA viruses induce apoptosis and apoptosis-associated pathology are not fully understood. Here we show that flock house virus (FHV), one of the simplest RNA viruses (family, Nodaviridae), induces robust apoptosis of permissive Drosophila Line-1 (DL-1) cells. To define the pathway by which FHV triggers apoptosis in this model invertebrate system, we investigated the potential role...

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PMID: 17989181
DOI: 10.1128/jvi.01941-07

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