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Article

Impact of CYP2C9 polymorphism found in the Chinese population on the metabolism of propofol in vitro.

Biological & pharmaceutical bulletin - 1 Jan 2015

Lian Qing-Quan, Pan Pei-Pei, Li Jun-Wei, Lin Han, Hu Guo-Xin, Zuo Ming-Zhang, Cai Jian-Ping

Abstract excerpt

The microsomal CYP2C9 alleles involved in the biotransformation of propofol, a widely used anesthetic agent, were investigated in vitro. To examine the enzymatic activity of the CYP2C9 alleles, kinetic parameters for propofol 4-hydroxylation were determined in recombinant human P450s CYP2C9 micro...

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Identifiers

PMID: 25832633
DOI: 10.1248/bpb.b14-00671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25832633-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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