Article
MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype.
American journal of physiology. Heart and circulatory physiology - 1 Aug 2003
Frangogiannis Nikolaos G, Mendoza Leonardo H, Ren Guofeng, Akrivakis Spyridon, Jackson Peggy L, Michael Lloyd H, Smith C Wayne, Entman Mark L
Abstract excerpt
Myocardial infarction is associated with the rapid induction of mononuclear cell chemoattractants that promote monocyte infiltration into the injured area. Monocyte-to-macrophage differentiation and macrophage proliferation allow a long survival of monocytic cells, critical for effective healing of the infarct. In a canine infarction-reperfusion model, newly recruited myeloid leukocytes were markedly augmented...
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