Article
The geoepidemiology of type 1 diabetes.
Autoimmunity reviews - 1 Mar 2010
Borchers Andrea T, Uibo Raivo, Gershwin M E
Abstract excerpt
Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by absolute insulin deficiency resulting from the progressive immune-mediated destruction of pancreatic islet beta cells. It is thought to be triggered by as yet unidentified environmental factors in genetically susceptible individuals, the major genetic contribution coming from loci within the HLA complex, in particular HLA class II. The...
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