Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.

Cell metabolism - 1 Oct 2006

Agostini Maura, Schoenmakers Erik, Mitchell Catherine, Szatmari Istvan, Savage David, Smith Aaron, Rajanayagam Odelia, Semple Robert, Luan Jian'an, Bath Louise, Zalin Anthony, Labib Mourad, Kumar Sudhesh, Simpson Helen, Blom Dirk, Marais David, Schwabe John, Barroso Inês, Trembath Richard, Wareham Nicholas, Nagy Laszlo, Gurnell Mark, O'Rahilly Stephen, Chatterjee Krishna

Abstract excerpt

PPARgamma is essential for adipogenesis and metabolic homeostasis. We describe mutations in the DNA and ligand binding domains of human PPARgamma in lipodystrophic, severe insulin resistance. These receptor mutants lack DNA binding and transcriptional activity but can translocate to the nucleus,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Insulin Resistance

Share to Lipodystrophy

Share to PPAR gamma

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 17011503
DOI: 10.1016/j.cmet.2006.09.003
PMCID: PMC1821092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17011503-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.PMID 17011503Read ↗

A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis.Semantic proximity Read ↗

PPARγ mutations, lipodystrophy and diabetes.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor-gamma and insulin action: insights from human genetics.Semantic proximity Read ↗

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.Semantic proximity Read ↗

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension.Semantic proximity Read ↗

Altered promoter recycling rates contribute to dominant-negative activity of human peroxisome proliferator-activated receptor-gamma mutations associated with diabetes.Semantic proximity Read ↗

Clinical and molecular characterization of a severe form of partial lipodystrophy expanding the phenotype of PPARγ deficiency.Semantic proximity Read ↗

New PPARG mutation leads to lipodystrophy and loss of protein function that is partially restored by a synthetic ligandSemantic proximity Read ↗

Functional implications of genetic variation in human PPARgamma.Semantic proximity Read ↗

A dominant negative PPARgamma mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells.Semantic proximity Read ↗

A genetic mutation in PPAR gamma is associated with enhanced fat cell differentiation: implications for human obesity.Semantic proximity Read ↗

PPARgamma in human and mouse physiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.