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Article

Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug treatment in temporal lobe epilepsy.

Seizure - 1 Jan 2015

Manna Ida, Gambardella Antonio, Labate Angelo, Mumoli Laura, Ferlazzo Edoardo, Pucci Franco, Aguglia Umberto, Quattrone Aldo

Abstract excerpt

PURPOSE: A synonymous C to T variant at position 3435 (c.3435C>T) is one common polymorphism of the multidrug resistant 1 (MDR1) gene, which encodes the major transmembrane efflux transporter P-glycoprotein. It has been suggested that this polymorphism, and more specifically the 3435CC genotype, may be associated with the response to antiepileptic drug treatment. Here we wished to examine the role of such a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25458099
DOI: 10.1016/j.seizure.2014.09.010

Genes

ABCB1

Variants

Provenance

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