Article
Coincidental LOH regions in mouse and humans: evidence for novel tumor suppressor loci at 9q22-q34 in non-Hodgkin's lymphomas.
Leukemia research - 1 Jul 2003
Meléndez Bárbara, Cuadros Marta, Robledo Mercedes, Rivas Carmen, Fernández-Piqueras José, Martínez-Delgado Beatriz, Benítez Javier
Abstract excerpt
Using an animal model for the study of murine thymic lymphomas, frequent losses of heterozygosity (LOHs) on six chromosomal regions were reported. To determine the existence of LOH loci in human lymphomas, we screened 43 non-Hodgkin's lymphomas by using polymorphisms mapped in each of the orthologous human region. All LOH regions (1p32-p36, 9p21, 9p22-p23, 9q22-q34 and 10q23-q24) were observed in B-cell lymphomas...
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