Fibroblast growth factors lead to increased Msx2 expression and fusion in calvarial sutures.

Abstract excerpt

Craniosynostosis, the premature fusion of the skull bones at the sutures, represents a disruption to the coordinated growth and development of the expanding brain and calvarial vault and is the second most common birth defect that affects the craniofacial complex. Mutations in the human homeobox-containing gene, Msx2, have been shown to cause Boston type craniosynostosis, and we have shown that overexpression of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Division
• Share to Craniosynostoses