Article
Involvement of APOBEC3B in mutation induction by irradiation.
Journal of radiation research - 16 Nov 2020
Saito Yohei, Miura Hiromasa, Takahashi Nozomi, Kuwahara Yoshikazu, Yamamoto Yumi, Fukumoto Manabu, Yamamoto Fumihiko
Abstract excerpt
To better understand the cancer risk posed by radiation and the development of radiation therapy resistant cancer cells, we investigated the involvement of the cancer risk factor, APOBEC3B, in the generation of radiation-induced mutations. Expression of APOBEC3B in response to irradiation was determined in three human cancer cell lines by real-time quantitative PCR. Using the hypoxanthine-guanine phosphoribosyl...
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