Article
Binding, internalisation and degradation of histatin 3 in histatin-resistant derivatives of Candida albicans.
FEMS microbiology letters - 28 Mar 2003
Fitzgerald Deirdre H, Coleman David C, O'Connell Brian C
Abstract excerpt
The antifungal mechanism of salivary histatin has been studied in Candida albicans and involves binding to a specific receptor, translocation across the membrane and targeting intracellularly. Cell death correlates with non-lytic release of ATP that may function as a cytotoxic mediator extracellularly. By sequential exposure to increasing concentrations of histatin 3, we generated histatin-resistant derivatives...
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