Article
mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish.
Experimental gerontology - 1 Apr 2003
Ross Owen A, McCormack Rose, Maxwell Lynn D, Duguid R Alistair, Quinn Derek J, Barnett Yvonne A, Rea I Maeve, El-Agnaf Omar M A, Gibson J Mark, Wallace Andrew, Middleton Derek, Curran Martin D
Abstract excerpt
Polymorphism of the mtDNA genome has been implicated as playing a role in the development and pathogenesis of Parkinson's disease (PD). A PCR-RFLP methodology was employed to generate genetic haplotypes for a cohort of 90 PD sufferers. No association was observed between the various mtDNA haplotypes observed and PD in comparison to healthy aged controls. The longevity-associated European J haplogroup and T...
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