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Article

Reduced hepatic tumor incidence in cyclin G1-deficient mice.

Hepatology (Baltimore, Md.) - 1 Apr 2003

Jensen Michael Rugaard, Factor Valentina M, Fantozzi Anna, Helin Kristian, Huh Chang-Goo, Thorgeirsson Snorri S

Abstract excerpt

Cyclin G1 is a transcriptional target of the tumor suppressor p53, and its expression is increased after DNA damage. Recent data show that cyclin G1 can regulate the levels of p53 by a mechanism that involves dephosphorylation of Mdm2 by protein phosphatase 2A. To understand the biologic role of cyclin G1, we have generated cyclin G1-deficient mice. In agreement with previous results, we showed that these mice...

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Identifiers

PMID: 12668979
DOI: 10.1053/jhep.2003.50137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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