Article
A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity.
Carcinogenesis - 1 Aug 2000
Ramljak D, Calvert R J, Wiesenfeld P W, Diwan B A, Catipovic B, Marasas W F, Victor T C, Anderson L M, Gelderblom W C
Abstract excerpt
Fumonisin B(1) (FB(1)) is a worldwide corn contaminant and has been epidemiologically linked to the high incidence of human esophageal cancer in South Africa and China. FB(1) is hepatocarcinogenic in rats by an unknown mechanism. Inhibition of ceramide synthase and disruption of membrane phospholipids have been shown to be mechanisms of toxicity. Here we show overexpression of cyclin D1 protein in both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.