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Article

p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability.

Molecular and cellular biology - 1 Jan 2008

Payne Shannon R, Zhang Shulin, Tsuchiya Karen, Moser Russell, Gurley Kay E, Longton Gary, deBoer Johan, Kemp Christopher J

Abstract excerpt

p27(kip1) is a cyclin-dependent kinase inhibitor and a tumor suppressor. In some tumors, p27 suppresses tumor growth by inhibition of cell proliferation. However, this is not universally observed, implying additional mechanisms of tumor suppression by p27. p27-deficient mice are particularly susceptibility to genotoxin-induced tumors, suggesting a role for p27 in the DNA damage response. To test this hypothesis,...

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Identifiers

PMID: 17954563
DOI: 10.1128/MCB.01536-07
PMCID: PMC2223298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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