Article
Maid (GCIP) is involved in cell cycle control of hepatocytes.
Hepatology (Baltimore, Md.) - 1 Feb 2007
Sonnenberg-Riethmacher Eva, Wüstefeld Torsten, Miehe Michaela, Trautwein Christian, Riethmacher Dieter
Abstract excerpt
UNLABELLED: The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice-in contrast to wild-type controls--develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH)....
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