Article
Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1.
Pharmacogenetics - 1 Apr 2003
Risch Angela, Ramroth Heribert, Raedts Vivianne, Rajaee-Behbahani Nahid, Schmezer Peter, Bartsch Helmut, Becher Heiko, Dietz Andreas
Abstract excerpt
OBJECTIVE: Alcohol and tobacco consumption are recognized risk factors for upper aerodigestive tract tumours, however individual susceptibility to these environmental factors varies. As part of the Rhein-Neckar Larynx-case-control study, this study investigated the potential risk-modifying effect of genetic polymorphisms in enzymes involved in ethanol and tobacco carcinogen metabolism for laryngeal cancer in...
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