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Article

Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.

Human genomics - 28 Nov 2016

Jorge-Nebert Lucia F, Zhang Ge, Wilson Keith M, Jiang Zhengwen, Butler Randall, Gluckman Jack L, Pinney Susan M, Nebert Daniel W

Abstract excerpt

BACKGROUND: Head-and-neck squamous cell carcinoma (HNSCC) differs between smokers and nonsmokers in etiology and clinical presentation. Because of demonstrated unequivocal involvement in smoking-induced cancer in laboratory animals, four candidate genes--AHR, CYP1A1, CYP1A2, and CYP1B1--were selected for a clinical genotype-phenotype association study of HNSCC risk in smokers. Thirty-six single-nucleotide...

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Identifiers

PMID: 27894333
DOI: 10.1186/s40246-016-0094-y
PMCID: PMC5127090

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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