Article
Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes.
Pharmacogenetics - 1 Apr 2003
Maitland-van der Zee Anke-Hilse, Stricker Bruno H Ch, Klungel Olaf H, Mantel-Teeuwisse Aukje K, Kastelein John J P, Hofman Albert, Leufkens Hubertus G M, van Duijn Cornelia M, de Boer Anthonius
Abstract excerpt
Discontinuation and poor adherence to therapy are major problems during long-term treatment, particularly with cholesterol lowering drugs. Several studies have indicated that the cholesterol lowering effect of statins differs according to apolipoprotein (apo)E genotypes. Low-density lipoprotein-cholesterol lowering capacity appears to be smaller in subjects with the epsilon(4) allele. To assess whether the use of...
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