Article
SLCO1B1*5 Allele Is Associated With Atorvastatin Discontinuation and Adverse Muscle Symptoms in the Context of Routine Care.
Clinical pharmacology and therapeutics - 1 May 2022
Voora Deepak, Baye Jordan, McDermaid Adam, Narayana Gowda Smitha, Wilke Russell A, Nicole Myrmoe Anna, Hajek Catherine, Larson Eric A
Abstract excerpt
The SLCO1B1 genotype is known to influence patient adherence to statin therapy, in part by increasing the risk for statin-associated musculoskeletal symptoms (SAMSs). The SLCO1B1*5 allele has previously been associated with simvastatin discontinuation and SAMSs. Prior analyses of the relationship between SLCO1B1*5 and atorvastatin muscle side effects have been inconclusive due to insufficient power. We now...
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