Article
The effectiveness of hydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype.
Pharmacogenetics - 1 Nov 2002
Maitland-van der Zee Anke-Hilse, Stricker Bruno H, Klungel Olaf H, Kastelein John J, Hofman Albert, Witteman Jacqueline C, Breteler Monique M, Leufkens Hubertus G, van Duijn Cornelia M, de Boer Anthonius
Abstract excerpt
We aimed to assess whether the effectiveness of statins in the prevention of myocardial infarction, stroke and total mortality is influenced by apolipoprotein E (apoE) genotype in an elderly population. We used data from the Rotterdam Study, a prospective population-based cohort study in the Netherlands which started in 1990 and included 7983 subjects aged 55 years and older. Subjects who were treated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.