Article
A naturally occurring mutation in an ATP-binding domain of the recombination repair gene XRCC3 ablates its function without causing cancer susceptibility.
Human molecular genetics - 15 Apr 2003
Rafii Saeed, Lindblom Annika, Reed Malcolm, Meuth Mark, Cox Angela
Abstract excerpt
Inherited mutations of the BRCA1 and BRCA2 genes, whose protein products are necessary for the homology-directed DNA repair pathway, confer a dominant susceptibility to cancer. We have investigated whether mutations of genes encoding other components of the same DNA repair pathway can also affect cancer susceptibility. We have identified three novel non-synonymous substitutions in one such gene, encoding the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.