Article
Evolution and population genetics of the H-ras minisatellite and cancer predisposition.
Human molecular genetics - 15 Apr 2003
Langdon Jacqueline A, Armour John A L
Abstract excerpt
Case-control studies have implicated rare length H-ras minisatellite alleles in cancer risk. In Europeans, this locus has four common alleles, and a larger number of rare alleles; possession of a rare allele has been identified as a risk factor responsible for 5-10% of some cancers. This unusual model of predisposition has been controversial in case-control studies, but also makes characteristic predictions about...
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