Article
Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain.
Vision research - 1 Apr 2003
Qiao Xiaoxi, Pennesi Mark, Seong Eunju, Gao Hua, Burmeister Margit, Wu Samuel M
Abstract excerpt
The mocha mouse is a spontaneous mutant carrying a defective adaptor-like protein complex AP-3delta subunit. We examined retinal function and histology of the mocha mutant. We found that not only mocha homozygotes but also other littermates in the inbred strain are blind due to severe defects in both rod and cone photoreceptors on electroretinogram recordings. The functional deficit was caused by rapid, early...
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