Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break.

Molecular cell - 1 Mar 2003

Leroy Christophe, Lee Sang Eun, Vaze Moreshwar B, Ochsenbein Françoise, Ochsenbien Françoise, Guerois Raphaël, Haber James E, Marsolier-Kergoat Marie-Claude

Abstract excerpt

Saccharomyces cells suffering a DNA double-strand break (DSB) ultimately escape checkpoint-mediated G2/M arrest either by recovery once the lesion is repaired or by adaptation if the lesion proves irreparable. Cells lacking the PP2C-like phosphatases Ptc2 and Ptc3 are unable to adapt to a HO-indu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 2
Share to G2 Phase
Share to Glutathione Transferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitosis

Share to Phosphoprotein Phosphatases

Share to Phosphoric Monoester Hydrolases

Share to Protein Phosphatase 2

Share to Protein Phosphatase 2C

Source

Identifiers

PMID: 12667463
DOI: 10.1016/s1097-2765(03)00058-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12667463-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break.PMID 12667463Read ↗

Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae.Semantic proximity Read ↗

Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53.Semantic proximity Read ↗

Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae.Semantic proximity Read ↗

Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants.Semantic proximity Read ↗

Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

CDK targets Sae2 to control DNA-end resection and homologous recombination.Semantic proximity Read ↗

Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.Semantic proximity Read ↗

Phosphatase complex Pph3/Psy2 is involved in regulation of efficient non-homologous end-joining pathway in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Semantic proximity Read ↗

Type 2C protein phosphatases (PP2Cs) regulate cell proliferation in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The DNA damage checkpoint: A tale from budding yeastSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.