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Article

Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 May 2007

Guillemain Ghislaine, Ma Emilie, Mauger Sarah, Miron Simona, Thai Robert, Guérois Raphaël, Ochsenbein Françoise, Marsolier-Kergoat Marie-Claude

Abstract excerpt

In Saccharomyces cerevisiae, double-strand breaks (DSBs) activate DNA checkpoint pathways that trigger several responses including a strong G(2)/M arrest. We have previously provided evidence that the phosphatases Ptc2 and Ptc3 of the protein phosphatase 2C type are required for DNA checkpoint inactivation after a DSB and probably dephosphorylate the checkpoint kinase Rad53. In this article we have investigated...

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Identifiers

PMID: 17325030
DOI: 10.1128/MCB.00863-06
PMCID: PMC1899965

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae.PMID 17325030Read ↗

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break.Semantic proximity Read ↗

Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae.Semantic proximity Read ↗

Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53.Semantic proximity Read ↗

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.Semantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase.Semantic proximity Read ↗

Characterization of the activation domain of the Rad53 checkpoint kinase.Semantic proximity Read ↗

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.Semantic proximity Read ↗

Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.Semantic proximity Read ↗

Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation.Semantic proximity Read ↗

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Semantic proximity Read ↗

Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling PathwaySemantic proximity Read ↗

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