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Article

Phosphatase complex Pph3/Psy2 is involved in regulation of efficient non-homologous end-joining pathway in the yeast Saccharomyces cerevisiae.

PloS one - 1 Jan 2014

Omidi Katayoun, Hooshyar Mohsen, Jessulat Matthew, Samanfar Bahram, Sanders Megan, Burnside Daniel, Pitre Sylvain, Schoenrock Andrew, Xu Jianhua, Babu Mohan, Golshani Ashkan

Abstract excerpt

One of the main mechanisms for double stranded DNA break (DSB) repair is through the non-homologous end-joining (NHEJ) pathway. Using plasmid and chromosomal repair assays, we showed that deletion mutant strains for interacting proteins Pph3p and Psy2p had reduced efficiencies in NHEJ. We further observed that this activity of Pph3p and Psy2p appeared linked to cell cycle Rad53p and Chk1p checkpoint proteins....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24498054
DOI: 10.1371/journal.pone.0087248
PMCID: PMC3909046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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