Article
Conformational differences in Mycobacterium tuberculosis catalase-peroxidase KatG and its S315T mutant revealed by resonance Raman spectroscopy.
Biochemistry - 8 Apr 2003
Kapetanaki Sofia, Chouchane Salem, Girotto Stefania, Yu Shengwei, Magliozzo Richard S, Schelvis Johannes P M
Abstract excerpt
KatG from Mycobacterium tuberculosis is a heme-containing catalase-peroxidase, which belongs to the class I peroxidases and is important for activation of the prodrug isoniazid (INH), a front-line antituberculosis drug. In many clinical isolates, resistance to INH has been linked to mutations on the katG gene, and the most prevalent mutation, S315T, suggests that modification of the heme pocket has occurred....
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