Article
Resonance Raman spectroscopy of Compound II and its decay in Mycobacterium tuberculosis catalase-peroxidase KatG and its isoniazid resistant mutant S315T.
Journal of inorganic biochemistry - 1 Jun 2005
Kapetanaki Sofia M, Chouchane Salem, Yu Shengwei, Magliozzo Richard S, Schelvis Johannes P M
Abstract excerpt
The reaction of Mycobacterium tuberculosis KatG and the mutant KatG(S315T) with two different organic peroxides is studied using resonance Raman spectroscopy. For the first time, an intermediate is observed in a catalase-peroxidase with vibrations that are characteristic of Compound II. The observation of this intermediate is consistent with photoreduction of Compound I and is in agreement with the formation of...
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