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The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid.

Biochimie - 1 Nov 2012

Chang Cheng-Hsiang, Chen Yi-Chi, Tseng Sheng-Wei, Liu Yuan-Ting, Wen Hao-Yu, Li Wen-Hsuan, Huang Chiao-Ying, Ko Cheng-Yu, Wang Tsai-Ting, Wu Tung-Kung

Abstract excerpt

The Cys703 to Ile or His mutation within Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase ERG7 (ERG7(C703I/H)) generates an unusual truncated bicyclic rearranged intermediate, (8R,9R,10R)-polypoda-5,13E,17E,21-tetraen-3β-ol, related to iridal-skeleton triterpenoid. Numerous oxidosqualene-cyclized truncated intermediates, including tricyclic, unrearranged tetracyclic with 17α/β exocyclic hydrocarbon side...

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PMID: 22732192
DOI: 10.1016/j.biochi.2012.06.014

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