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Article

Catalytic mechanism and product specificity of oxidosqualene-lanosterol cyclase: a QM/MM study.

The journal of physical chemistry. B - 29 Nov 2012

Tian Bo-Xue, Eriksson Leif A

Abstract excerpt

Oxidosqualene-lanosterol cyclase (OSC) is a key enzyme in the biosynthesis of cholesterol. The catalytic mechanism and the product specificity of OSC have herein been studied using QM/MM calculations. According to our calculations, the protonation of the epoxide ring of oxidosqualene is rate-limiting. Wild-type OSC (which generates lanosterol), and the mutants H232S (which generates parkeol) and H232T (which...

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Identifiers

PMID: 23130825
DOI: 10.1021/jp3091396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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