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Article

Enzymatic Addition of Alcohols to Terpenes by Squalene Hopene Cyclase Variants.

Chembiochem : a European journal of chemical biology - 16 Nov 2017

Kühnel Lisa C, Nestl Bettina M, Hauer Bernhard

Abstract excerpt

Squalene-hopene cyclases (SHCs) catalyze the polycyclization of squalene into a mixture of hopene and hopanol. Recently, amino-acid residues lining the catalytic cavity of the SHC from Alicyclobacillus acidocaldarius were replaced by small and large hydrophobic amino acids. The alteration of leucine 607 to phenylalanine resulted in increased enzymatic activity towards the formation of an intermolecular...

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PMID: 28898524
DOI: 10.1002/cbic.201700449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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