Article
A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2016
Salmon Melissa, Thimmappa Ramesha B, Minto Robert E, Melton Rachel E, Hughes Richard K, O'Maille Paul E, Hemmings Andrew M, Osbourn Anne
Abstract excerpt
Triterpenes are structurally complex plant natural products with numerous medicinal applications. They are synthesized through an origami-like process that involves cyclization of the linear 30 carbon precursor 2,3-oxidosqualene into different triterpene scaffolds. Here, through a forward genetic screen in planta, we identify a conserved amino acid residue that determines product specificity in triterpene...
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