Article
In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2003
Umeda Jiro, Sano Shigetoshi, Kogawa Kazuhiko, Motoyama Noboru, Yoshikawa Kunihiko, Itami Satoshi, Kondoh Gen, Watanabe Takeshi, Takeda Junji
Abstract excerpt
To investigate the function of Bcl-xL in the skin, we established keratinocyte-specific Bcl-x gene-targeted mice under the keratin 5 promoter (K5). K5.Bcl-xL-/- mice were viable, devoid of alteration in the development of skin or appendages. However, they harbored spontaneous apoptotic keratinocytes in the epidermis. Bcl-xL-deficient keratinocytes cultured in vitro readily underwent apoptosis in the absence of...
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