Article
Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.
The Journal of biological chemistry - 6 Jul 2001
Nomura M, Kaji A, Ma W Y, Zhong S, Liu G, Bowden G T, Miyamoto K I, Dong Z
Abstract excerpt
In this study, we investigated the mechanism by which UVB irradiation activates Akt (also known as protein kinase B (PKB)) in mouse epidermal JB6 cells. Treatment with a phosphatidylinositol 3-kinase inhibitor, LY 294002, or expression of a dominant negative mutant of p85 (regulatory component of phosphatidylinositol 3-kinase) inhibited UVB-induced Akt activation. Interestingly, Akt activation by UVB was...
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