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Article

Involvement of the Apoptotic Mechanism in Pemphigus Foliaceus Autoimmune Injury of the Skin

1 Jan 2009

Abstract excerpt

Pemphigus foliaceus (PF) is an organ-specific autoimmune skin disease characterized by subcorneal epidermal cell detachment (acantholysis) and pathogenic autoantibodies against desmoglein 1. The mechanism responsible for pemphigus autoantibody-induced epidermal injury is not fully understood. In this study, we used the IgG passive transfer mouse model of PF to investigate the relevance of the apoptotic mechanism...

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PMID: 19109205
DOI: 10.4049/jimmunol.182.1.711

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