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Role of E2F transcription factor in oral cancer: Recent insight and advancements

14 Mar 2023

Abstract excerpt

The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to cell proliferation, apoptosis and differentiation, mainly in a cell cycle-dependent manner. E2F activity is frequently controlled via the retinoblastoma protein (pRb), cyclins, p53 and the...

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Identifiers

PMID: 36924812
DOI: 10.1016/j.semcancer.2023.03.004

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