Article
Epigenetic variability and the evolution of human cancer.
Advances in cancer research - 1 Jan 2003
Ohlsson Rolf, Kanduri Chandrasekhar, Whitehead Joanne, Pfeifer Susan, Lobanenkov Victor, Feinberg Andrew P
Abstract excerpt
Although the leading dogma for the origin of the diversity in cancer cell subpopulations is based on a stepwise selection and accumulation of genetic changes that allow uncontrollable malignant growth, there is an emerging understanding that the variability of heritable phenotypes in cancer and cancer-prone cells may also involve epigenetic mechanisms. We discuss here experimental data that allow us to postulate...
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