Article
Effects of hormone replacement therapy on serum angiotensin-converting enzyme activity and plasma bradykinin in postmenopausal women according to angiotensin-converting enzyme-genotype.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jan 2003
Sumino Hiroyuki, Ichikawa Shuichi, Ohyama Yoshio, Nakamura Tetsuya, Kanda Tsugiyasu, Sakamoto Hironosuke, Sakamaki Tetsuo, Mizunuma Hideki, Kurabayashi Masahiko
Abstract excerpt
An insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene determines serum ACE levels. The D allele is associated with increased ACE activity and is linked to cardiovascular disease. Hormone replacement therapy (HRT) in postmenopausal women (PMW) decreases serum ACE activity and concomitantly increases plasma bradykinin. We investigated the effect of HRT on these parameters in PMW...
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