Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations within the hepatitis C virus genotype 1b E2-PePHD domain do not correlate with treatment outcome.

Journal of clinical microbiology - 1 Feb 2005

Gaudy Catherine, Lambelé Marie, Moreau Alain, Veillon Pascal, Lunel Francoise, Goudeau Alain

Abstract excerpt

The hepatitis C virus (HCV) envelope protein 2 (E2) interacts in vitro with the interferon alpha (IFN-alpha)-inducible double-stranded RNA-activated protein kinase, suggesting a possible mechanism by which HCV may evade the antiviral effects of IFN-alpha. Variability in the part of the HCV E2 gene encoding the carboxy-terminal part of the protein, which includes the interaction domain (E2-PePHD), was explored in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Therapy, Combination

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C

Share to Interferon-alpha

Share to Ribavirin

Share to Treatment Outcome

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 15695675
DOI: 10.1128/JCM.43.2.750-754.2005
PMCID: PMC548054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations within the hepatitis C virus genotype 1b E2-PePHD domain do not correlate with treatment outcome.PMID 15695675Read ↗

Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response.Semantic proximity Read ↗

Mutations in the E2-PePHD and NS5A region of hepatitis C virus type 1 and the dynamics of hepatitis C viremia decline during interferon alfa treatment.Semantic proximity Read ↗

The protein kinase-interacting domain in the hepatitis C virus envelope glycoprotein-2 gene is highly conserved in genotype 1-infected patients treated with interferon.Semantic proximity Read ↗

Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon.Semantic proximity Read ↗

Quasispecies heterogeneity of the carboxy-terminal part of the E2 gene including the PePHD and sensitivity of hepatitis C virus 1b isolates to antiviral therapy.Semantic proximity Read ↗

Association of amino acid sequence in the PKR-eIF2 phosphorylation homology domain and response to interferon therapy.Semantic proximity Read ↗

Mutations in the NS5A and E2-PePHD regions of hepatitis C virus genotype 1b and response to combination therapy of interferon plus ribavirin.Semantic proximity Read ↗

Analysis of the PKR-eIF2alpha phosphorylation homology domain (PePHD) of hepatitis C virus genotype 1 in HIV-coinfected patients by ultra-deep pyrosequencing and its relationship to responses to pegylated interferon-ribavirin treatment.Semantic proximity Read ↗

Variations within hepatitis C virus E2 protein and response to interferon treatment.Semantic proximity Read ↗

Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection.Semantic proximity Read ↗

Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b.Semantic proximity Read ↗

Mutations within the CD81-binding sites and hypervariable region 2 of the envelope 2 protein: correlation with treatment response in hepatitis C virus-infected patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.