Article
Engrailed controls the organization of the ventral nerve cord through frazzled regulation.
Developmental biology - 15 Jan 2007
Joly Willy, Mugat Bruno, Maschat Florence
Abstract excerpt
In Drosophila, the ventral nerve cord (VNC) architecture is built from neuroblasts that are specified during embryonic development, mainly by transcription factors. Here we show that Engrailed, a homeodomain transcription factor known to be involved in the establishment of neuroblast identity, is also directly implicated in the regulation of axonal guidance cues. Posterior commissures (PC) are missing in...
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