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Mrx6 regulates mitochondrial DNA copy number inSaccharomyces cerevisiaeby engaging the evolutionarily conserved Lon protease Pim1

18 Sept 2019

Abstract excerpt

cells, revealing an epistatic relationship between Pim1 and Mrx6. Human and bacterial Lon proteases regulate DNA replication by degrading replication initiation factors, suggesting a model in which Pim1 acts similarly with the Mrx6 complex, providing a scaffold linking it to mtDNA.

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Identifiers

PMID: 31532710
DOI: 10.1091/mbc.e19-08-0470

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