Article
Frequency of mutation to rifampin resistance in Streptococcus pneumoniae clinical strains: hexA and hexB polymorphisms do not account for hypermutation.
Antimicrobial agents and chemotherapy - 1 Apr 2003
Morosini María-Isabel, Baquero María-Rosario, Sánchez-Romero J M, Negri María-Cristina, Galán Juan-Carlos, del Campo Rosa, Pérez-Díaz J C, Baquero Fernando
Abstract excerpt
The frequency of mutation to rifampin resistance of 200 clinical Streptococcus pneumoniae isolates was examined. Two peaks were observed in the distribution, with mode frequencies of 2.5 x 10(-7) (20% of isolates) and 2.5 x 10(-8). The hexA and hexB gene entire sequences were analyzed in 13 isolates. Sequences from both hypermutable and "normomutable" strains were conserved relative to that of the R6 S....
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