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Article

Polymorphisms at positions -22 and -348 in the promoter of the BAT1 gene affect transcription and the binding of nuclear factors.

Human molecular genetics - 1 May 2004

Price Patricia, Wong Agnes M-L, Williamson David, Voon Dominic, Baltic Svetlana, Allcock Richard J N, Boodhoo Alvin, Christiansen Frank T

Abstract excerpt

BAT1 (D6S81E, UAP56) lies in the central MHC between TNF and HLA-B, a region containing genes that affect susceptibility to immunopathologic disorders. BAT1 protein may be directly responsible for the genetic association, as antisense studies show it can down-regulate inflammatory cytokines. Here we investigate polymorphisms at positions -22 and -348 relative to the BAT1 transcription start site. DNA samples from...

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PMID: 15028669
DOI: 10.1093/hmg/ddh113

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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