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Article

Drug resistance to targeted therapies: Déjà vu all over again

21 May 2014

Abstract excerpt

A major limitation of targeted anticancer therapies is intrinsic or acquired resistance. This review emphasizes similarities in the mechanisms of resistance to endocrine therapies in breast cancer and those seen with the new generation of targeted cancer therapeutics. Resistance to single-agent cancer therapeutics is frequently the result of reactivation of the signaling pathway, indicating that a major...

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PMID: 24910388
DOI: 10.1016/j.molonc.2014.05.004

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