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Article

The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2006

van der Linden Ivon J M, den Heijer Martin, Afman Lydia A, Gellekink Henkjan, Vermeulen Sita H H M, Kluijtmans Leo A J, Blom Henk J

Abstract excerpt

The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in homocysteine remethylation. In some studies, the 66A>G polymorphism in the MTRR gene was associated with increased neural tube defect (NTD) risk. Using a cas...

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Source

Identifiers

PMID: 17024475
DOI: 10.1007/s00109-006-0093-x

Genes

MTRR
MTHFR
MTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17024475-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Click a neighbor to travelStep 1 · 12 closest

The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida.PMID 17024475Read ↗

A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.Semantic proximity Read ↗

Association between MTR A2756G and MTRR A66G polymorphisms and maternal risk for neural tube defects: a meta-analysis.Semantic proximity Read ↗

Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects.Semantic proximity Read ↗

Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida.Semantic proximity Read ↗

Analysis of MTR and MTRR Polymorphisms for Neural Tube Defects Risk Association.Semantic proximity Read ↗

Meta-analyses on the association of MTR A2756G and MTRR A66G polymorphisms with neural tube defect risks in Caucasian children.Semantic proximity Read ↗

MTRR 66A>G polymorphism as maternal risk factor for Down syndrome: a meta-analysis.Semantic proximity Read ↗

The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy.Semantic proximity Read ↗

Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes.Semantic proximity Read ↗

Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.Semantic proximity Read ↗

Association between the methionine synthase A2756G polymorphism and neural tube defect risk: a meta-analysis.Semantic proximity Read ↗

The association between methionine synthase reductase c.66A>G variant and the risk of recurrent pregnancy loss: A systematic review and meta-analysis.Semantic proximity Read ↗

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