Article
Subcellular daunorubicin distribution and its relation to multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R.
World journal of gastroenterology - 1 Aug 2002
Yang Jia-Yin, Luo Hua-You, Lin Qi-Yuan, Liu Zi-Ming, Yan Lu-Nan, Lin Ping, Zhang Jie, Lei Shong
Abstract excerpt
AIM: To investigate the correlation between subcellular daunorubicin distribution and the multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R. METHODS: The multidrug resistant cell line SMMC-7721/R, a human hepatocellular carcinoma cell line, was established. Antisense oligonucleotides (AS-ODN) were used to obtain different multidrug resistance phenotypes by inhibiting the expression of mdr1...
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